Peran Penting Inflamasom NLRP3 pada Aterosklerosis

Cardiovascular diseases (CVDs) still contribute as the main cause of mortality and premature worldwide. In Indonesia, CVDs to 35% death in non-communicable followed by diabetes at 6%. The ischemic heart disease acute stroke is Indonesia due atherosclerosis. Atherosclerosis a multifactorial cause, with chronic inflammation which causes myocardial infarction stroke. Research demonstrated that one underlying mechanisms atherosclerosis inflammation. current research suggested could activate complex cytosol proteins, namely nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome. NLRP3 inflammasome known protein sensor response danger signals pathogen-associated molecular patterns (PAMPs) or damage/danger-associated (DAMPs). will convert pro-IL1β pro-IL-18 into their mature forms initiates cell (pyroptosis) through cleavage Caspase-1. This has central role initiation progression affecting sequences its cellular targets. To date, several small molecules drugs have been identified inhibitory pathways potential therapeutic agents for this review, we discuss further structure roles atherosclerosis, candidates targeted pathway.